Opportunity Information: Apply for RFA OD 24 009
The National Institutes of Health (NIH), through the Office of the Director (OD), is seeking applications for a cooperative agreement to serve as the Data Coordinating and Operations Center (DCOC) for the Environmental influences on Child Health Outcomes (ECHO) IDeA States Pediatric Clinical Trials Network (ECHO ISPCTN). This opportunity is focused on organizations located in Institutional Development Award (IDeA)-eligible states and is meant to create the central hub that coordinates, standardizes, and operationally supports a network of pediatric clinical trial sites. The DCOC and separately funded Clinical Sites (solicited under a companion clinical sites announcement running in parallel) together make up the ECHO ISPCTN, which is described as the intervention arm of the broader ECHO Program and aligns with ECHOs mission of improving childrens health over the long term.
The DCOC is expected to enable the design and execution of roughly five multicenter pediatric clinical trials during the award period. These trials must focus on prevention and/or treatment interventions and align with ECHOs five priority child health outcome areas: (1) pre-, peri-, and postnatal outcomes, (2) upper and lower airways, (3) obesity, (4) neurodevelopment, and (5) positive health. Collectively, the planned trials are expected to cover at least two of these five areas, meaning the overall portfolio should not be limited to a single outcome domain. A central purpose of structuring the network this way is to produce results that are valid and generalizable by using rigorous methods and by recruiting and retaining participant numbers large enough to justify multicenter trial designs.
A defining emphasis of this network is reaching children and families in rural or underserved communities within IDeA states. The DCOC is expected to support clinical sites in ways that make high-quality trials feasible in these settings, while also strengthening long-term pediatric clinical trial capacity across IDeA-state institutions. In addition to technical coordination, the DCOC is also expected to promote meaningful engagement with interested parties such as community members, nonprofit organizations, and professional societies. The intent is to improve trial impact and real-world usefulness by strengthening rigor, feasibility, transferability, and the relevance of research questions and intervention approaches to participating communities.
Administratively, this is a discretionary funding opportunity using a cooperative agreement mechanism (U24), which typically means NIH will have substantial programmatic involvement in how the center and network operate compared with a standard grant. The funding opportunity number is RFA-OD-24-009, and the original application closing date listed is 2024-06-14. The activity is categorized under areas including education, health, income security, and social services, and it is associated with CFDA numbers 93.279, 93.310, 93.859, and 93.865. The award ceiling and expected number of awards are not specified in the provided listing, but the description makes clear that the DCOC budget is intended to support coordination for an approximately five-trial multicenter portfolio.
Eligibility is broad across U.S.-based domestic organizations, but the announcement specifically targets participation from entities in IDeA-eligible states for this DCOC role. Eligible applicants include various levels of government (state, county, city/township, special districts), independent school districts, public and private institutions of higher education, federally recognized tribal governments and certain tribal organizations, public housing authorities, nonprofits (both 501(c)(3) and non-501(c)(3)), for-profit organizations (other than small businesses), and small businesses. The notice also highlights categories of other eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and certain Indian/Native American tribal governments that are not federally recognized. At the same time, it clearly excludes non-U.S. applicants and foreign involvement: non-domestic (non-U.S.) entities are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components are not allowed as defined by NIH policy.
In practical terms, an applicant proposing to be the DCOC would be positioning itself as the networks operational backbone: the group responsible for the coordinated infrastructure that allows multiple clinical sites to run harmonized pediatric intervention trials, enroll and retain adequate numbers of participants across diverse and often hard-to-reach communities, ensure consistent and high-quality data collection and trial operations, and support dissemination of findings. The overarching goal is to generate strong evidence about interventions that can improve child health outcomes, with particular attention to the needs and realities of families in rural and underserved IDeA-state communities.Apply for RFA OD 24 009
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "Data Coordinating and Operations Center for the ECHO IDeA States Pediatric Clinical Trials Network - 3 (U24 Clinical Trial RequiredInfrastructure)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279, 93.310, 93.859, 93.865.
- This funding opportunity was created on 2024-01-19.
- Applicants must submit their applications by 2024-06-14. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs): NIH ECHO IDeA States Pediatric Clinical Trials Network (ECHO ISPCTN) - Data Coordinating and Operations Center (DCOC)
1) What is this funding opportunity?
This is a National Institutes of Health (NIH) funding opportunity to support a cooperative agreement (U24) for a Data Coordinating and Operations Center (DCOC) for the Environmental influences on Child Health Outcomes (ECHO) IDeA States Pediatric Clinical Trials Network (ECHO ISPCTN).
2) What is the role of the Data Coordinating and Operations Center (DCOC)?
The DCOC is intended to function as the network's central hub. It coordinates, standardizes, and provides operational support so multiple pediatric clinical trial sites can run harmonized multicenter intervention trials, with consistent trial operations and high-quality data collection across sites.
3) What is the ECHO ISPCTN?
The ECHO IDeA States Pediatric Clinical Trials Network (ECHO ISPCTN) is described as the intervention arm of the broader ECHO Program. It consists of the DCOC plus separately funded Clinical Sites that are being solicited under a companion clinical sites announcement running in parallel.
4) How does the DCOC relate to the Clinical Sites?
The DCOC and the Clinical Sites are funded separately but are designed to work together as one network (the ECHO ISPCTN). The DCOC provides the coordinating infrastructure and operational backbone that helps enable multicenter trials across the participating clinical sites.
5) What type of award mechanism is being used?
The mechanism is a cooperative agreement (U24). This typically means NIH expects substantial programmatic involvement in how the center and network operate compared with a standard grant.
6) What is the funding opportunity number (FOA number)?
The funding opportunity number is RFA-OD-24-009.
7) What was the application due date listed in the opportunity description?
The original application closing date listed is 2024-06-14.
8) What is the main purpose of structuring the network with a central DCOC?
A core purpose is to produce results that are valid and generalizable by using rigorous methods and by recruiting and retaining participant numbers large enough to justify multicenter pediatric clinical trial designs.
9) How many trials is the DCOC expected to support?
The DCOC is expected to enable the design and execution of roughly five multicenter pediatric clinical trials during the award period.
10) What kinds of trials are expected (observational or intervention)?
The planned trials must focus on prevention and/or treatment interventions, and are intended to be multicenter pediatric clinical trials.
11) What child health outcome areas must the trials align with?
The trials must align with ECHO's five priority child health outcome areas:
- Pre-, peri-, and postnatal outcomes
- Upper and lower airways
- Obesity
- Neurodevelopment
- Positive health
12) Do the trials have to cover more than one ECHO outcome area?
Yes. Collectively, the planned trials are expected to cover at least two of the five ECHO priority outcome areas, so the overall network portfolio is not limited to a single domain.
13) Is there an emphasis on particular communities or settings?
Yes. A defining emphasis is reaching children and families in rural or underserved communities within IDeA states, and supporting clinical sites to make high-quality trials feasible in these settings.
14) What longer-term capacity goal is included in the description?
Beyond supporting individual trials, the DCOC is expected to help strengthen long-term pediatric clinical trial capacity across IDeA-state institutions.
15) What does the DCOC need to do besides technical coordination?
In addition to technical and operational coordination, the DCOC is expected to promote meaningful engagement with interested parties such as community members, nonprofit organizations, and professional societies, to improve trial impact and real-world usefulness.
16) Why is engagement with community and other interested parties emphasized?
The intent is to improve rigor, feasibility, transferability, and relevance of research questions and intervention approaches to participating communities, which in turn is expected to improve the practical usefulness and impact of trial findings.
17) Who is the sponsor for this opportunity?
The sponsor is the National Institutes of Health (NIH), through the Office of the Director (OD).
18) Is this opportunity limited to organizations in IDeA-eligible states?
Eligibility is described as broad across U.S.-based domestic organizations, but the opportunity specifically targets participation from organizations located in IDeA-eligible states for the DCOC role.
19) What types of organizations are eligible to apply?
Eligible applicants include a wide range of U.S.-based domestic entities, including:
- State, county, city/township governments, special districts
- Independent school districts
- Public and private institutions of higher education
- Federally recognized tribal governments and certain tribal organizations
- Public housing authorities
- Nonprofits (501(c)(3) and non-501(c)(3))
- For-profit organizations (other than small businesses)
- Small businesses
20) Are minority-serving institutions and community-based organizations included as eligible applicants?
Yes. The notice highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, HBCUs, TCCUs, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions, among others listed.
21) Are non-U.S. (foreign) organizations eligible to apply?
No. Non-domestic (non-U.S.) entities are not eligible to apply.
22) Can a U.S. organization include a non-U.S. component or foreign component in the application?
No. The description states that non-domestic components of U.S. organizations are not eligible, and foreign components are not allowed as defined by NIH policy.
23) What areas does the opportunity fall under in the listing?
The activity is categorized under areas including education, health, income security, and social services.
24) What CFDA numbers are associated with this opportunity?
The listing associates the opportunity with CFDA numbers 93.279, 93.310, 93.859, and 93.865.
25) Is the award ceiling specified? Is the expected number of awards specified?
No. The award ceiling and the expected number of awards are not specified in the provided listing. The description does state that the DCOC budget is intended to support coordination for an approximately five-trial multicenter portfolio.
26) What is the overarching goal of the DCOC and network?
The overarching goal is to generate strong evidence about prevention and/or treatment interventions that can improve child health outcomes over the long term, with particular attention to the needs and realities of families in rural and underserved communities within IDeA states.
27) What is meant by the DCOC being the "operational backbone" of the network?
Based on the description, it means the DCOC is responsible for the coordinated infrastructure that allows multiple clinical sites to run harmonized pediatric intervention trials, recruit and retain adequate numbers of participants across diverse and hard-to-reach communities, and ensure consistent, high-quality trial operations and data collection.
28) Do the planned trials need to be multicenter?
Yes. The DCOC is expected to enable multicenter pediatric clinical trials, and the rationale described includes enrolling and retaining enough participants to justify multicenter designs.
29) What is the intended impact of running harmonized multicenter trials across IDeA states?
The intent described is to strengthen methodological rigor and produce results that are valid and generalizable, while also making trials feasible in rural and underserved settings and building long-term clinical trial capacity in IDeA-state institutions.
30) Does the opportunity description indicate that the network is part of the broader ECHO mission?
Yes. The ECHO ISPCTN is described as aligning with ECHO's mission of improving children's health over the long term.
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