Opportunity Information: Apply for PAR 19 177
The High-End Instrumentation (HEI) Grant Program (PAR 19-177) is a National Institutes of Health (NIH) funding opportunity designed to help institutions acquire or upgrade one major piece of cutting-edge, commercially available scientific equipment (or an integrated instrumentation system) that is too costly to be easily supported through typical research project grants. The program is aimed at shared-use, high-impact instrumentation that will serve a group of NIH-supported investigators, strengthening their ability to carry out advanced biomedical and behavioral research. This opportunity is explicitly marked as "S10 Clinical Trial Not Allowed," meaning it supports research infrastructure (instrumentation) rather than the conduct of clinical trials under this award mechanism.
A central feature of the HEI program is its focus on a single, expensive, specialized instrument or system rather than multiple smaller purchases. The funding range is substantial, with a minimum award amount of $600,001 and a maximum award amount of $2,000,000. This scale is intended for high-end platforms that can transform or significantly expand an institution's research capabilities, especially when the instrument will be broadly accessible to a user group rather than dedicated to only one lab. While the opportunity supports either purchasing a new instrument or upgrading an existing one, the emphasis remains on enabling advanced research through shared, state-of-the-art technology.
The types of instruments that fit this program include a wide variety of sophisticated research platforms commonly used in modern biomedical science. Examples listed in the announcement include X-ray diffraction systems, nuclear magnetic resonance (NMR) spectrometers, mass spectrometers, DNA and protein sequencers, biosensors, electron and confocal microscopes, cell sorters, and biomedical imaging systems. The list is not exhaustive, which signals that NIH is open to other comparable high-end instruments as long as they are specialized, commercially available, expensive enough to fall within the program's cost range, and clearly justified by the scientific needs of the NIH-supported user group.
Eligibility is geared toward U.S.-based organizations with the capacity to operate and manage shared instrumentation resources. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, and nonprofit organizations (including both 501(c)(3) nonprofits and nonprofits without 501(c)(3) status, as long as they are not institutions of higher education where relevant). The opportunity also highlights that several categories of institutions are included among eligible applicants, such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs). These categories reflect NIH's broader interest in ensuring that research infrastructure support can reach a diverse range of institutions and research communities.
At the same time, the announcement is clear about restrictions related to foreign involvement. Non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply. In addition, non-domestic components of U.S. organizations are not eligible to apply, and foreign components (as NIH defines them in the NIH Grants Policy Statement) are not allowed. In practical terms, the instrument and the benefiting activity are expected to be U.S.-based, with the supported research community and operational management anchored domestically.
From an administrative perspective, this is a discretionary grant opportunity under the NIH, falling within the Health funding activity category, and associated with CFDA numbers 93.351 and 93.859. The opportunity title and number identify it as an S10 instrumentation program, which is commonly used at NIH to support shared instrumentation acquisition and upgrades. The original closing date shown in the source data is May 31, 2019, and the creation date is January 29, 2019; applicants should always verify current submission windows and any reissued or updated announcements, since NIH often renews or replaces older funding announcements over time.
Overall, the HEI program is best understood as an infrastructure investment mechanism: it helps institutions secure major, high-cost instruments that can be operated as shared resources for multiple NIH-funded investigators, improving research capability, throughput, and technical sophistication. Competitive applications typically hinge on demonstrating a strong and well-defined user group, clear scientific need, a credible plan for access and scheduling, appropriate staffing and technical support, and a sustainable approach to operating and maintaining the instrument so it delivers long-term value to NIH-supported research.Apply for PAR 19 177
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "High-End Instrumentation (HEI) Grant Program (S10 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.351, 93.859.
- This funding opportunity was created on 2019-01-29.
- Applicants must submit their applications by 2019-05-31. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public and State controlled institutions of higher education, Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, Others.
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High-End Instrumentation (HEI) Grant Program (PAR 19-177) FAQs
What is the High-End Instrumentation (HEI) Grant Program (PAR 19-177)?
The High-End Instrumentation (HEI) Grant Program (PAR 19-177) is a National Institutes of Health (NIH) funding opportunity that helps eligible institutions acquire or upgrade one major piece of high-end, commercially available scientific equipment (or an integrated instrumentation system). The goal is to strengthen advanced biomedical and behavioral research by supporting shared-use instrumentation that is too expensive to be easily funded through typical research project grants.
What does "S10 Clinical Trial Not Allowed" mean for this opportunity?
"S10 Clinical Trial Not Allowed" indicates the award is for research infrastructure (instrumentation) and not for conducting clinical trials under this award mechanism. In other words, the grant supports purchasing or upgrading equipment rather than running a clinical trial.
What is the main purpose of this program?
The program is designed to increase an institution's research capacity by funding a single, high-impact instrument or integrated system that will be shared by a group of NIH-supported investigators. The emphasis is on broad access and significant research benefit, rather than equipment dedicated to a single laboratory.
How many instruments can be requested under this program?
The opportunity is centered on acquiring or upgrading one major piece of cutting-edge equipment (or an integrated instrumentation system). It is not intended to support multiple smaller equipment purchases.
Does the HEI program support buying a new instrument, upgrading an existing one, or both?
Both are supported. The program can fund the purchase of a new high-end instrument or the upgrade of an existing instrument, as long as the request is for a single major instrument or integrated system and fits the program's intent and cost range.
What is the funding range for an HEI award?
The funding range is large by design: the minimum award amount is $600,001 and the maximum award amount is $2,000,000. This range is meant to cover expensive, specialized platforms that can significantly expand research capabilities.
What types of instruments are considered a fit for this program?
The announcement provides examples of sophisticated research platforms, including X-ray diffraction systems, nuclear magnetic resonance (NMR) spectrometers, mass spectrometers, DNA and protein sequencers, biosensors, electron and confocal microscopes, cell sorters, and biomedical imaging systems. The list is not exhaustive, which suggests other comparable high-end instruments may be considered if they are commercially available, specialized, appropriately costly, and strongly justified by the needs of the NIH-supported user group.
Does the instrument have to be commercially available?
Yes. The opportunity is described as supporting cutting-edge, commercially available scientific equipment or integrated instrumentation systems.
What does "shared-use" mean in the context of this grant?
"Shared-use" refers to an instrument that is broadly accessible to a defined group of NIH-supported investigators rather than reserved for one lab. The program prioritizes instrumentation that will serve multiple users and deliver high impact across an institution's research community.
Who is expected to benefit from the instrument purchased or upgraded with HEI funds?
The instrument is intended to serve a group of NIH-supported investigators. The focus is on supporting advanced biomedical and behavioral research by strengthening the capabilities of multiple researchers through shared access to state-of-the-art equipment.
What types of organizations are eligible to apply?
Eligibility is geared toward U.S.-based organizations that can operate and manage shared instrumentation resources. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, and nonprofit organizations (including 501(c)(3) nonprofits and nonprofits without 501(c)(3) status, as applicable).
Are minority-serving and tribal institutions included in the eligible categories?
Yes. The opportunity highlights that eligible applicants include, among others, Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and related categories.
Are foreign (non-U.S.) institutions eligible to apply?
No. Non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply for this opportunity.
Can a U.S. organization apply if the instrument or activity involves a non-U.S. (foreign) component?
The announcement states that non-domestic components of U.S. organizations are not eligible to apply and that foreign components (as NIH defines them in the NIH Grants Policy Statement) are not allowed. In practical terms, the instrument and the benefiting activity are expected to be U.S.-based and managed domestically.
What is the funding agency and funding category for this opportunity?
The funding agency is the National Institutes of Health (NIH). The opportunity is described as a discretionary grant and is associated with the Health funding activity category.
What CFDA numbers are associated with this grant opportunity?
The opportunity is associated with CFDA numbers 93.351 and 93.859.
What does it mean that this is an "S10" instrumentation program?
The opportunity title and number identify it as an S10 instrumentation program, which NIH commonly uses to support acquisition and upgrades of shared research instrumentation.
What are the dates listed for this opportunity?
The source information lists a creation date of January 29, 2019, and an original closing date of May 31, 2019.
Should applicants rely on the listed closing date as the current deadline?
No. The information notes that applicants should verify current submission windows and check for reissued or updated announcements, since NIH may renew, replace, or update older funding announcements over time.
What kinds of application elements are implied to matter for a competitive HEI proposal?
Based on the description, competitive applications typically depend on demonstrating a strong and well-defined NIH-supported user group, a clear scientific need for the instrument, and credible plans for shared access and scheduling. The description also points to the importance of appropriate staffing and technical support, along with a sustainable approach to operating and maintaining the instrument so it provides long-term value.
Is this program best viewed as a research project grant?
No. The opportunity is best understood as an infrastructure investment mechanism. It funds acquisition or upgrade of major instrumentation to enable and strengthen research, rather than funding the research itself as a traditional project award would.
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