Opportunity Information: Apply for RFA MH 17 361

The Improving the HIV Pre-Exposure Prophylaxis (PrEP) Cascade (R34) funding opportunity (RFA-MH-17-361) is a National Institutes of Health (NIH) discretionary grant program designed to help applicants plan, develop, and pilot test practical interventions that strengthen the oral PrEP "care continuum" (often called the PrEP cascade). The core purpose is to improve real-world PrEP delivery by addressing common drop-off points such as getting people linked to PrEP services, keeping them engaged in ongoing PrEP care, supporting consistent medication adherence, and promoting long-term persistence on PrEP for as long as it remains clinically indicated. In other words, this announcement focuses less on proving PrEP works biologically (that is already well established) and more on improving the systems, services, and strategies that help people start and successfully stay on PrEP.

This FOA uses the R34 Planning Grant mechanism, which typically supports early-stage work needed to prepare for a larger clinical or implementation research effort. Under this announcement, applicants are expected to design and refine interventions and then conduct pilot testing to see whether the approach is feasible, acceptable, and shows enough promise to justify a subsequent, larger-scale study. The emphasis is on strengthening the PrEP continuum among individuals at substantial risk for HIV infection, with intervention targets that can include engagement and retention in PrEP clinical care (for example, reducing missed visits, improving follow-up, strengthening patient navigation, or removing structural barriers) and, when appropriate, interventions that support medication adherence and persistence (for example, adherence supports, reminder systems, counseling strategies, peer or community-based support, or clinic workflow improvements that make ongoing PrEP use easier).

The opportunity is categorized under Education and Health and is associated with multiple CFDA numbers (93.242, 93.279, 93.855, 93.856), reflecting NIH program alignment across relevant research and public health domains. The funding instrument is a grant, with an award ceiling listed at $225,000. The original closing date for the opportunity was January 6, 2017, and the posting creation date was September 23, 2016. While the announcement is dated, the summary of intent remains useful as a description of what NIH sought to stimulate at the time: intervention development and pilot testing aimed at measurable improvements across the PrEP cascade.

Eligibility is broad and includes many types of domestic U.S. applicants: state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); public housing authorities/Indian housing authorities; Native American tribal organizations other than federally recognized tribal governments; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; and small businesses. The FOA also explicitly highlights additional eligible applicant categories, emphasizing inclusion of organizations that often serve populations disproportionately affected by HIV or facing barriers to prevention services. These include Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); faith-based or community-based organizations; Hispanic-serving institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American tribal governments other than federally recognized entities; Tribally Controlled Colleges and Universities (TCCUs); U.S. territories or possessions; and, notably, non-domestic (non-U.S.) entities (foreign organizations) and regional organizations, indicating that applicants could propose work in varied geographic and organizational contexts when aligned with the FOA aims.

Overall, the R34 PrEP Cascade opportunity is best understood as a planning and pilot-testing vehicle to move beyond awareness of PrEP and toward better delivery and sustained use in everyday settings. It supports applicants who want to develop and test interventions that keep people connected to PrEP services over time and help them take PrEP consistently, ultimately aiming to reduce HIV incidence by making PrEP programs more effective, durable, and responsive to the needs of people at highest risk.

  • The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Improving the HIV Pre-Exposure Prophylaxis (PrEP) Cascade (R34)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242, 93.279, 93.855, 93.856.
  • This funding opportunity was created on 2016-09-23.
  • Applicants must submit their applications by 2017-01-06. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $225,000.00 in funding.
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
Apply for RFA MH 17 361

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