Opportunity Information: Apply for RFA NS 18 032
The Research Program Award (R35 Clinical Trial Optional), funding opportunity number RFA-NS-18-032, is a National Institute of Neurological Disorders and Stroke (NINDS) grant program designed to give established NINDS-funded investigators longer-term, more flexible support for their overall neuroscience research programs. Instead of funding a narrowly defined set of specific aims over a typical grant cycle, this award is intended to back a investigator's broader, ongoing research direction, recognizing a strong track record of accomplishment and the likelihood of continued major contributions to neuroscience. The central idea is to create a more stable funding base so investigators can pursue ambitious questions, shift directions when new findings emerge, and take calculated scientific risks that might be harder to justify in a traditional, tightly scoped application.
A key feature of the R35 RPA is its duration and stability: it can support an eligible investigator's research program for up to 8 years. The funding level is described as being commensurate with the Program Director/Principal Investigator's recent NINDS support, meaning the award amount is generally aligned with what the investigator has been receiving from NINDS rather than being purely a de novo request untethered from prior funding patterns. The opportunity is labeled "Clinical Trial Optional," which signals that clinical trials may be proposed if appropriate, but they are not required; the emphasis is on the strength and promise of the overall research program within NINDS priorities.
The program is also framed around practical benefits for research productivity and the scientific workforce. By consolidating support into a longer, more flexible mechanism, NINDS aims to reduce the constant churn of writing and resubmitting multiple grant applications and managing overlapping awards. That time savings is expected to translate into more hands-on scientific leadership, better oversight of complex projects, and increased capacity for mentoring trainees and junior scientists. The flexible structure is explicitly meant to allow investigators to respond to opportunities as they arise, including extending earlier discoveries into new areas, initiating longer-horizon projects, or pivoting toward emerging questions that may not fit neatly into pre-specified aims.
Research funded under this R35 must fall squarely within the NINDS mission. Projects that are outside NINDS scientific scope, or that are more typically supported by another NIH Institute or Center, are not intended for this program. In other words, the award is not a general neuroscience grant without boundaries; it is a mechanism for supporting high-performing NINDS investigators to advance neurological research that aligns with NINDS priorities.
Eligibility is intentionally narrow and tied to sustained recent NINDS support. Applicants must be investigators who currently have at least one active NINDS R01 or equivalent award that is due to expire in fiscal year (FY) 2018 or FY 2019. For this purpose, "R01 equivalent" is defined to include R01, R37, R56, DP1, or DP2 awards. In addition, applicants must have had NINDS support through an R01, R00, or R01-equivalent grant in each of the past five years, with the allowance that no more than one of those years may have been covered by a no-cost extension. This structure targets investigators with an established, continuous record of NINDS-funded research rather than new entrants who are still building that record.
From the administrative and funding details provided, this is a discretionary grant opportunity administered by the U.S. Department of Health and Human Services through NIH/NINDS, listed under CFDA 93.853 (health-related research support). A broad range of organization types are listed as eligible applicants in the general opportunity data, including various government entities, higher education institutions (public and private), nonprofits, and for-profit organizations (excluding small businesses in one category but also explicitly including small businesses in another), as well as other entities as clarified in the full announcement. In practice, however, the investigator-level eligibility requirements tied to current and sustained NINDS R01-class support are the gating factor for who can realistically apply.
The opportunity was created May 11, 2018, with an original closing date of July 13, 2018. The expected number of awards was 30, and the listed award ceiling was $750,000. Overall, the R35 RPA is best understood as an NINDS mechanism to invest in proven investigators by giving them multi-year stability and latitude to run a coherent, evolving neuroscience research program, with the goal of accelerating impactful discoveries while reducing administrative burden and strengthening mentorship capacity.Apply for RFA NS 18 032
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Research Program Award (R35 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853.
- This funding opportunity was created on May 11, 2018.
- Applicants must submit their applications by Jul 13, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $750,000.00 in funding.
- The number of recipients for this funding is limited to 30 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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