Opportunity Information: Apply for W81XWH 20 PRMRP TTDA

The CDMRP Peer Reviewed Medical Research Program (PRMRP) Technology/Therapeutic Development Award (TTDA) is a Department of Defense funding opportunity focused on turning strong preclinical research findings into practical medical products that can be used in real-world clinical settings. It is explicitly product-driven, meaning the core expectation is not just generating new scientific knowledge, but building something that is meaningfully positioned to move forward toward clinical use. Supported products can target prevention, detection, diagnosis, treatment, or improvements in quality of life, and they must align with at least one of the Congressionally directed FY20 PRMRP Topic Areas. A central emphasis is relevance to the healthcare needs of military Service members, Veterans, and/or other beneficiaries, so proposed products should be clearly connected to those populations and their medical realities.

The award supports development of a wide range of product types. This includes tangible items such as drugs, biologics, and medical devices, as well as "knowledge-based products." In this program, a knowledge product is described as a non-materiel output designed to meet an identified medical need within a topic area and to transition into practice. These can include clinical tools, training approaches, decision supports, guidelines, or other evidence-based resources that educate or influence behavior across the continuum of care, including primary prevention. Knowledge products can also be intended to support or enable materiel solutions by informing how medical capabilities are developed, acquired, delivered, and sustained.

A key requirement is that the Principal Investigator includes a credible transition plan showing what happens after the award period ends. This plan should explain how the product will progress to the next stage of development, such as entry into clinical trials or movement toward delivery in military or civilian markets. The transition plan is expected to identify potential future funding sources and resources, reflecting that this award is meant to be a bridge toward downstream implementation rather than a standalone research endpoint. Applicants are also encouraged to build relationships with industry partners and/or other funding organizations to improve the likelihood that the product can successfully advance beyond the funded period.

Administratively, the opportunity (Funding Opportunity Number W81XWH-20-PRMRP-TTDA) is offered by the Department of Defense, Department of the Army, through USAMRAA. The assistance instruments include grants and cooperative agreements, and it falls under the Science and Technology and other Research and Development activity category (CFDA 12.420). Eligibility is listed as unrestricted, meaning it is open to a wide range of entity types unless further limitations are specified elsewhere in the full announcement. The posting date is February 28, 2020, with an original closing date of August 20, 2020, and the program anticipated making around 14 awards. The listed award ceiling is shown as 0 in the provided record, which typically indicates the ceiling is not captured in that field and would need to be confirmed in the full solicitation documents.

  • The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "CDMRP Peer Reviewed Medical Research Program Technology/Therapeutic Development Award" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
  • This funding opportunity was created on Feb 28, 2020.
  • Applicants must submit their applications by Aug 20, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The number of recipients for this funding is limited to 14 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
Apply for W81XWH 20 PRMRP TTDA

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FAQs: CDMRP PRMRP Technology/Therapeutic Development Award (TTDA)

What is the PRMRP Technology/Therapeutic Development Award (TTDA)?

The PRMRP TTDA is a Department of Defense funding opportunity under the Congressionally Directed Medical Research Programs (CDMRP) that supports efforts to translate strong preclinical research findings into practical medical products intended for real-world clinical settings.

Is this award primarily research-focused or product-focused?

It is explicitly product-driven. The main expectation is to develop something positioned to move toward clinical use, rather than focusing only on generating new scientific knowledge.

What kinds of outcomes or products can be supported?

Supported products can target prevention, detection, diagnosis, treatment, or improvements in quality of life, as long as they align with at least one of the Congressionally directed FY20 PRMRP Topic Areas.

What product types are eligible under this program?

The program supports a wide range of product types, including drugs, biologics, medical devices, and knowledge-based products designed to transition into practice.

What is a "knowledge-based product" in the context of this award?

A knowledge-based product is a non-materiel output designed to meet an identified medical need within a topic area and to transition into practice. Examples described for this program include clinical tools, training approaches, decision supports, guidelines, and other evidence-based resources that educate or influence behavior across the continuum of care, including primary prevention.

Can knowledge-based products support materiel solutions like devices or drugs?

Yes. Knowledge products may also be intended to support or enable materiel solutions by informing how medical capabilities are developed, acquired, delivered, and sustained.

What is the required connection to military or Veteran health?

A central emphasis is relevance to the healthcare needs of military Service members, Veterans, and/or other beneficiaries. Proposed products should be clearly connected to those populations and their medical realities.

Do proposed products need to align with specific topic areas?

Yes. Products must align with at least one of the Congressionally directed FY20 PRMRP Topic Areas.

Is a transition plan required?

Yes. The Principal Investigator is required to include a credible transition plan that explains what happens after the award period ends and how the product will progress to the next stage of development.

What should a transition plan address?

The transition plan should describe the intended next stage of development (for example, entry into clinical trials or movement toward delivery in military or civilian markets) and identify potential future funding sources and resources to support downstream implementation.

Is this award intended to be a standalone research endpoint?

No. The award is framed as a bridge toward downstream implementation, with a clear expectation that the work will be positioned to advance beyond the funded period.

Are applicants encouraged to involve industry or other partners?

Yes. Applicants are encouraged to build relationships with industry partners and/or other funding organizations to improve the likelihood that the product can advance after the award ends.

Who is the sponsoring agency for this opportunity?

The opportunity is offered by the Department of Defense, Department of the Army, through USAMRAA (U.S. Army Medical Research Acquisition Activity).

What is the Funding Opportunity Number (FON)?

The Funding Opportunity Number is W81XWH-20-PRMRP-TTDA.

What funding instruments are used for this opportunity?

The assistance instruments include grants and cooperative agreements.

What is the CFDA number and category for this program?

The program is listed under CFDA 12.420 and falls within the Science and Technology and other Research and Development activity category.

Who is eligible to apply?

Eligibility is listed as unrestricted, meaning it is open to a wide range of entity types unless additional limitations are described elsewhere in the full announcement.

When was the opportunity posted and what were the close dates?

The posting date is February 28, 2020. The original closing date is August 20, 2020.

How many awards were anticipated?

The program anticipated making around 14 awards.

What is the maximum award amount (award ceiling)?

The award ceiling is shown as 0 in the provided record, which typically indicates the ceiling was not captured in that field. The actual ceiling would need to be confirmed in the full solicitation documents.

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