Opportunity Information: Apply for SP 21 002
The Grants to Prevent Prescription Drug/Opioid Overdose-Related Deaths (PDO) opportunity is a discretionary federal grant program run by the U.S. Department of Health and Human Services through the Substance Abuse and Mental Health Services Administration (SAMHSA), specifically its Center for Substance Abuse Treatment (CSAT). Released for fiscal year 2021, this program is designed to help communities reduce fatal and non-fatal overdose events tied to prescription opioids and other opioids, with a clear focus on adults age 18 and older. The core idea is to strengthen local overdose prevention and response capacity by combining practical training for people most likely to encounter overdoses with on-the-ground secondary prevention strategies that can immediately save lives.
A central feature of the grant is workforce and community training. The program supports training for first responders such as law enforcement, firefighters, and emergency medical services, but it also emphasizes "other key community sectors" that may be positioned to intervene during an overdose event or help prevent one. In practice, that can include organizations and personnel in places like public health, behavioral health, community-based outreach, and other local partners who regularly interact with populations at risk. The training component is aimed at improving recognition of overdose signs, appropriate emergency actions, and effective use of overdose reversal medications, along with broader prevention practices intended to reduce overdose-related adverse events.
Alongside training, the opportunity funds secondary prevention strategies, most notably the purchase and distribution of naloxone for first responders. Naloxone is a widely used opioid overdose reversal medication, and expanding access to it is a direct, evidence-based tactic to reduce overdose deaths when administered quickly. The grant framework highlights implementation, meaning applicants are expected not only to plan but to put systems in place for getting naloxone into the field and ensuring trained personnel can use it confidently and appropriately. The program is specifically framed around preventing deaths and adverse events, signaling that SAMHSA is looking for measurable improvements in real-world overdose outcomes, not just educational activities.
From an administrative standpoint, the funding opportunity title is "Grants to Prevent Prescription Drug/Opioid Overdose-Related Deaths," with Funding Opportunity Number SP 21 002. It falls under the Health funding activity category and is associated with CFDA number 93.243. The opportunity was created on December 30, 2020, with an original application closing date of March 1, 2021. SAMHSA anticipated making about 13 awards under this announcement, and the listed award ceiling is $850,000, indicating awards can be substantial enough to support coordinated training, procurement, and distribution activities across a community or region.
Eligibility is listed as "Others," with additional eligibility details referenced in the full announcement text. In other words, this was not limited only to state governments or a single class of applicants, but applicants were expected to consult SAMHSA's detailed eligibility language to confirm their fit. Overall, the PDO grant opportunity is best understood as a targeted overdose-death prevention initiative that funds communities to build practical overdose response readiness, expand naloxone availability for first responders, and implement proven secondary prevention steps that can immediately reduce opioid overdose mortality among adults.Apply for SP 21 002
- The Department of Health and Human Services, Substance Abuse and Mental Health Services Adminis in the health sector is offering a public funding opportunity titled "Grants to Prevent Prescription Drug/Opioid Overdose-Related Deaths" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.243.
- This funding opportunity was created on Dec 30, 2020.
- Applicants must submit their applications by Mar 01, 2021. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $850,000.00 in funding.
- The number of recipients for this funding is limited to 13 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
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| STOP DJEKOIDJO Apply for 72062421RFA00002 Funding Number: 72062421RFA00002 Agency: Agency for International Development, Cote d Ivoire USAID - Abidjan Category: Health Funding Amount: $19,500,000 |
| Paul Coverdell National Acute Stroke Program Apply for CDC RFA DP21 2102 Funding Number: CDC RFA DP21 2102 Agency: Department of Health and Human Services, Centers for Disease Control - NCCDPHP Category: Health Funding Amount: $650,000 |
| Next Generation Sequencing in Post Mortem Tissue from Patients with Parkinsons Disease (U01 Clinical Trial Not Allowed) Apply for RFA NS 21 017 Funding Number: RFA NS 21 017 Agency: Department of Health and Human Services, National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Partnering with Professional and Medical Associations to Increase Vaccination Coverage Across Different Racial and Ethnic Adult Populations Experiencing Disparities Apply for CDC RFA IP21 2107 Funding Number: CDC RFA IP21 2107 Agency: Department of Health and Human Services, Centers for Disease Control - NCIRD Category: Health Funding Amount: Case Dependent |
| The CDC National Centers of Excellence in Youth Violence Prevention (YVPCs): Rigorous Evaluation of Prevention Strategies to Prevent and Reduce Community Rates of Youth Violence Apply for RFA CE 21 005 Funding Number: RFA CE 21 005 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $1,200,000 |
| Emerging Issues in Maternal and Child Health Apply for HRSA 21 080 Funding Number: HRSA 21 080 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $250,000 |
| Identify and Evaluate Potential Risk Factors for Amyotrophic Lateral Sclerosis (ALS) Apply for RFA TS 21 001 Funding Number: RFA TS 21 001 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $500,000 |
| Supporting Laboratory Systems Strengthening Activities in Ghana under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH21 2110 Funding Number: CDC RFA GH21 2110 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: $250,000 |
| Comprehensive Access to HIV/AIDS Care and Treatment, and Prevention Services for Key Populations in Haiti under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH21 2111 Funding Number: CDC RFA GH21 2111 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Comprehensive HIV/AIDS Service Delivery Programs in Haiti under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH21 2112 Funding Number: CDC RFA GH21 2112 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Achieving and Sustaining Epidemic Control Through Comprehensive HIV/AIDS Prevention, Care and Treatment Services in Machakos, Makueni and Kitui Counties in Kenya under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH21 2116 Funding Number: CDC RFA GH21 2116 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Technical assistance to the Government of Kenya and Implementing Partners Towards Sustained Health Information Systems and Digital Health Solutions for HIV/TB Epidemic Control in Kenya under the US President's Emergency Plan for AIDS Relief (PEP Apply for CDC RFA GH21 2114 Funding Number: CDC RFA GH21 2114 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Building Sustainable Health Systems and Laboratory Services in Cote d'Ivoire under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH21 2151 Funding Number: CDC RFA GH21 2151 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Supporting the Implementation and Expansion of High Quality, Sustainable and Comprehensive HIV Prevention, Care and Treatment Programs in Nairobi County in the Republic of Kenya under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH21 2115 Funding Number: CDC RFA GH21 2115 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Supporting the Sustainable Implementation of Comprehensive High-Quality HIV Prevention, Care and Treatment Programs in the Western Region of the Republic of Kenya under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH21 2119 Funding Number: CDC RFA GH21 2119 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Building Vietnam's M&E Capacity for Program Monitoring, Data Visualization, Data Use, Linking Private and Public Networks and Supporting HIV Clinical Services at Site and Provincial Levels under the President's Emergency Plan for AIDS R Apply for CDC RFA GH21 2144 Funding Number: CDC RFA GH21 2144 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Enhancing Sustainable and Integrated Health, Strategic Information and Laboratory Systems for Quality Comprehensive HIV Services through Technical Assistance to the Republic of Rwanda under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH21 2142 Funding Number: CDC RFA GH21 2142 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Providing Quality Voluntary Medical Male Circumcision (VMMC) Services to Support HIV Prevention Efforts in Botswana under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH21 2141 Funding Number: CDC RFA GH21 2141 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
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