Opportunity Information: Apply for SP 21 002

The Grants to Prevent Prescription Drug/Opioid Overdose-Related Deaths (PDO) opportunity is a discretionary federal grant program run by the U.S. Department of Health and Human Services through the Substance Abuse and Mental Health Services Administration (SAMHSA), specifically its Center for Substance Abuse Treatment (CSAT). Released for fiscal year 2021, this program is designed to help communities reduce fatal and non-fatal overdose events tied to prescription opioids and other opioids, with a clear focus on adults age 18 and older. The core idea is to strengthen local overdose prevention and response capacity by combining practical training for people most likely to encounter overdoses with on-the-ground secondary prevention strategies that can immediately save lives.

A central feature of the grant is workforce and community training. The program supports training for first responders such as law enforcement, firefighters, and emergency medical services, but it also emphasizes "other key community sectors" that may be positioned to intervene during an overdose event or help prevent one. In practice, that can include organizations and personnel in places like public health, behavioral health, community-based outreach, and other local partners who regularly interact with populations at risk. The training component is aimed at improving recognition of overdose signs, appropriate emergency actions, and effective use of overdose reversal medications, along with broader prevention practices intended to reduce overdose-related adverse events.

Alongside training, the opportunity funds secondary prevention strategies, most notably the purchase and distribution of naloxone for first responders. Naloxone is a widely used opioid overdose reversal medication, and expanding access to it is a direct, evidence-based tactic to reduce overdose deaths when administered quickly. The grant framework highlights implementation, meaning applicants are expected not only to plan but to put systems in place for getting naloxone into the field and ensuring trained personnel can use it confidently and appropriately. The program is specifically framed around preventing deaths and adverse events, signaling that SAMHSA is looking for measurable improvements in real-world overdose outcomes, not just educational activities.

From an administrative standpoint, the funding opportunity title is "Grants to Prevent Prescription Drug/Opioid Overdose-Related Deaths," with Funding Opportunity Number SP 21 002. It falls under the Health funding activity category and is associated with CFDA number 93.243. The opportunity was created on December 30, 2020, with an original application closing date of March 1, 2021. SAMHSA anticipated making about 13 awards under this announcement, and the listed award ceiling is $850,000, indicating awards can be substantial enough to support coordinated training, procurement, and distribution activities across a community or region.

Eligibility is listed as "Others," with additional eligibility details referenced in the full announcement text. In other words, this was not limited only to state governments or a single class of applicants, but applicants were expected to consult SAMHSA's detailed eligibility language to confirm their fit. Overall, the PDO grant opportunity is best understood as a targeted overdose-death prevention initiative that funds communities to build practical overdose response readiness, expand naloxone availability for first responders, and implement proven secondary prevention steps that can immediately reduce opioid overdose mortality among adults.

  • The Department of Health and Human Services, Substance Abuse and Mental Health Services Adminis in the health sector is offering a public funding opportunity titled "Grants to Prevent Prescription Drug/Opioid Overdose-Related Deaths" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.243.
  • This funding opportunity was created on Dec 30, 2020.
  • Applicants must submit their applications by Mar 01, 2021. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $850,000.00 in funding.
  • The number of recipients for this funding is limited to 13 candidate(s).
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
Apply for SP 21 002

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Frequently Asked Questions (FAQs): Grants to Prevent Prescription Drug/Opioid Overdose-Related Deaths (PDO)

What is the PDO grant opportunity?

The Grants to Prevent Prescription Drug/Opioid Overdose-Related Deaths (PDO) opportunity is a discretionary federal grant program intended to help communities reduce fatal and non-fatal overdose events tied to prescription opioids and other opioids. It focuses on strengthening local overdose prevention and response capacity through training and secondary prevention strategies.

Which federal agency runs this program?

The program is run by the U.S. Department of Health and Human Services (HHS) through the Substance Abuse and Mental Health Services Administration (SAMHSA), specifically SAMHSA's Center for Substance Abuse Treatment (CSAT).

What fiscal year does the provided announcement relate to?

The information provided describes the opportunity as released for fiscal year (FY) 2021.

What is the main purpose of the PDO grant?

The main purpose is to reduce overdose deaths and adverse events by improving real-world overdose response readiness and implementing secondary prevention strategies that can immediately save lives, including expanded access to naloxone for first responders.

Who is the primary population focus for this grant?

The grant has a clear focus on adults age 18 and older.

What kinds of activities does the grant support?

Based on the provided information, the grant supports (1) workforce and community training to improve overdose recognition and response, and (2) secondary prevention strategies, most notably purchasing and distributing naloxone for first responders.

What does the training component cover?

The training is aimed at improving recognition of overdose signs, appropriate emergency actions, and effective use of overdose reversal medications. It also supports broader prevention practices intended to reduce overdose-related adverse events.

Who can be trained under this program?

The program supports training for first responders such as law enforcement, firefighters, and emergency medical services (EMS). It also emphasizes training for "other key community sectors" positioned to intervene during an overdose event or help prevent one.

What are examples of "other key community sectors" mentioned in the description?

The description notes that, in practice, other key sectors can include organizations and personnel in public health, behavioral health, community-based outreach, and other local partners who regularly interact with populations at risk.

Does the grant support naloxone?

Yes. A highlighted secondary prevention strategy is the purchase and distribution of naloxone for first responders. Naloxone is described as a widely used opioid overdose reversal medication, and expanding access is framed as an evidence-based tactic to reduce overdose deaths when administered quickly.

Is this program focused on planning, implementation, or both?

The framework highlights implementation. The description indicates applicants are expected not only to plan but to put systems in place for getting naloxone into the field and ensuring trained personnel can use it confidently and appropriately.

What outcomes is SAMHSA looking for?

The opportunity is specifically framed around preventing deaths and adverse events. The description suggests SAMHSA is looking for measurable improvements in real-world overdose outcomes, not only educational activities.

What is the Funding Opportunity Number for this announcement?

The Funding Opportunity Number is SP 21 002.

What is the official title of the funding opportunity?

The title is "Grants to Prevent Prescription Drug/Opioid Overdose-Related Deaths."

What funding activity category is associated with this grant?

The opportunity falls under the Health funding activity category.

What is the CFDA number associated with this program?

The program is associated with CFDA number 93.243.

When was this opportunity created?

The opportunity was created on December 30, 2020.

What was the original application closing date?

The original application closing date listed is March 1, 2021.

How many awards did SAMHSA anticipate making?

SAMHSA anticipated making about 13 awards under this announcement.

What is the maximum award amount (award ceiling)?

The listed award ceiling is $850,000.

Who is eligible to apply based on the provided information?

Eligibility is listed as "Others," with additional eligibility details referenced in the full announcement text. This indicates the program was not limited only to state governments or a single class of applicants, and applicants were expected to consult SAMHSA's detailed eligibility language to confirm eligibility.

Is this grant limited to prescription opioids only?

No. The description states it targets overdose events tied to prescription opioids and other opioids.

What is meant by "secondary prevention strategies" in this description?

In this context, secondary prevention strategies are described as on-the-ground steps that can immediately save lives during or around overdose events. The most prominent example given is the purchase and distribution of naloxone for first responders, paired with implementation systems and training so it can be used effectively.

What is the overall summary of what this program funds communities to do?

Overall, the PDO opportunity is described as a targeted overdose-death prevention initiative that funds communities to build practical overdose response readiness, expand naloxone availability for first responders, and implement proven secondary prevention steps to reduce opioid overdose mortality among adults.

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